Hepatitis E Treatment, Vaccine, Diagnosis, Transmission

Hepatitis E Treatment, Vaccine, Diagnosis, Transmission

Hepatitis E Treatment, Vaccine, Diagnosis, Transmission

What is Hepatitis E?

Hepatitis E is a type of hepatitis e virus inflammation of the liver that causes hepatitis e virus infection (HEV). The main route of hepatitis E is a hepatitis A-like, fecal-oral transmission, although viruses have no link.

The first known hepatitis E epidemic occurred in New Delhi in 1955 but Russian researchers who investigated an outbreak in Afghanistan did not isolate the virus until 1983.

HEV is a positive, nonenveloped RNA icosahedral and one of the fünf known viruses of human hepatitis: A, B , C , D and E. HEV has no positive effect.

It usually follows an acute and self-limiting course of disease in resource-rich areas (the condition is temporary and the individual recovered).

In embryonic women and people with a weakened immune system, however, it may be more severe with significantly greater mortality rates.

The disease is more frequent in pregnant women , particularly in the third quarter, and is associated with a clinical syndrome known as respiteful liver failure with a death rate of approximately 20%.

Women who are pregnant with a quick and severe course can have a slower and more persistent form called chronic hepatitis E, diagnotized after 3 months of continuous viremium, which allows organ transplant receivers who receive drugs to weaken the immune system and prevent rejections of the organ.

Genetically, HEV can be clustered into 8 genotypes, and genotypes 3 and 4 are generally the cause of chronic immunosuppressed hepatitis.

Mode Of Transmission

It is endenemic and can result in outbreaks in Southeast Asia, Northern and Central Africa , India and Central America (Gen. 1 and, to a lesser extent, Gen. 2).

It is mainly propagated by fecal / oral route because of water or food contamination; direct transmission from person to person is rare.

Unlike genotypes 1 and 2, 3 and 4, sporadic cases of animal direct contact or of contaminated water or meat are considered zoonotic, causing sporadic cases.

Epidemic hepatitis E outbreaks most often occur after heavy rains, especially monsoons due to disrupted water supplies; heavy floods can lead to water contaminating waste.

78 The World Health Organisation ‘s recommendation for chlore for inactivation of HEV has been given for 30 minutes (pH, < 8.0) Free chlore residual of 0.5 mg / L (6.710−5 oz / US gal) According to Rein et al., HEV genotype 1 and HEV 2, together with 3,4 million symptotic disease cases and 70,000 deaths in 2005, caused approximately 20,1 million hepatitis-E infections but the previous document did not estimate genotype burden 3 nor 4.


Only a laboratory blood test can be relied on to confirm the presence of HEVRNA or IgM anticorps against HEV with regard to the diagnosis of hepatitis E.

In the USA, the Food and Drug Administration has never approved serologic tests to diagnose HEV infection.

In the case of acute infection the viremic window for the detection of HEV RNA closes three weeks after signs start. HEV RNA can be detected by the viremic window for the acute disease.

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